When I think about translational possibilities from my lab, I'm drawing on my many years of experience in biotech-what technologies, at the moment, are likely to find customers or partners, as well as investors, and fill an unmet need for patients. The Pipeline Repertoire for Ig-Seq Analysis With the advent of high-throughput sequencing of immunoglobulin genes (Ig-Seq), the understanding of antibody repertoires and their dynamics among individuals and populations has become an exciting area of research. One's discoveries need to be almost immediately appealing to potential partners. Because the biotech institutional investor space has changed so much-fewer groups with less capital-one cannot rely on traditional models of using investment to translate and commercialize discoveries. imAEs are also called immune-related adverse events (irAEs) and measuring the immune repertoire may help indicate if a patient will have. Robinson Abstract The development of high-throughput DNA sequencing technologies has enabled large-scale characterization of functional antibody repertoires, a new method of understanding protective and pathogenic immune responses. I have learned much by engaging with potential partners and customers very early in the process of commercializing discoveries. Using RNA-Seq, ImReP is able to capture on average 53.3 of the IGH repertoire, estimated as the sum of detected BCR-seq-confirmed clonotypes MiXCR is able to capture 40.1 (Fig. Immune-mediated adverse events (imAEs) are indeed one of the limiting factors for development of cancer treatments, resulting in patients needing to be nursed back to health in carefully monitored environments. While we in academia have great ideas about how to apply and develop our discoveries, what matters more is what those willing to pay for the discoveries would like to buy. Our method does not capture localized selection pressures (such as avoiding self). LS: If one considers the 'lean startup' model espoused in the IT space, the most salient concept that translates to biotech is one of engaging early with customers and partners, as opposed to institutional investors. The immune cell repertoire of a given individual is comprised of many clones. 33650440 DOI: 10.1080/08916934.2021.1887149 Abstract The diversity of the immune repertoire (IR) enables the human immune system to distinguish multifarious antigens (Ags) that humans may encounter throughout life.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |